Dr K K Aggarwal President CMAAO, HCFI,
With input from Dr Monica Vasudev
1433: Local reaction to Moderna’s COVID-19 vaccine
1. can appear up to 11 days after vaccination and symptoms can persist for as long as 11 days, a team of Boston doctors warns in an online letter to The New England Journal of Medicine.
2. Their analysis of 12 patients with delayed reactions after the first dose of the vaccine found that when delayed reactions occurred, the median time to onset was 8 days and symptoms resolved after a median of 6 days.
3. Reactions didn’t always occur at the injection site. A 40-year-old woman developed papules on her palm and fingers that were believed to be the result of a shot. A 43-year-old man developed urticarial plaques on his elbows.
4. Many patients have unnecessarily received antibiotic agents" to treat them
5. About 84% of people who get their first dose of the Moderna vaccine have some type of reaction, such a muscle soreness or tenderness, and 0.8% of patients in the initial vaccine trial reported a delayed injection-site reaction on or after 8 days.
6. A delayed reaction such as erythema, induration and tenderness was less common — seen in 0.2% of patients — after the second dose. Most symptoms resolved after 5 days.
7. Recipients saw any immediate side effects disappear, only to have a reaction sometime between 4 to 11 days after the first dose. Their symptoms persisted for 2 to 11 days.
8. Five of the reactions in the 12 patients produced grade 3 plaques, meaning their diameter was at least 10 cm in diameter. Some had systemic symptoms associated with the vaccination.
